Curcumin and Turmeric supplement 500 mg, 60 capsules
Joint Power Rx with turmeric, curcumin, boswellia, glucosamine and chondroitin
Developed by Ray Sahelian, M.D.
Curcumin extract is one of the major antioxidant extracts found in the spice turmeric. The roots of the turmeric plant are used as an herb in Asian cooking such as curries. Curcumin is a major component of turmeric herb (Curcuma longa) and extensive scientific research on curcumin and turmeric has demonstrated their potent antioxidant properties. Through their antioxidant mechanisms, curcumin and turmeric support colon health, exert neuroprotective activity and help maintain a healthy cardiovascular system.

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Curcumin supplement facts:
Curcumin extract and Turmeric herb 500 mg *
Usage: Take 1 or 2 curcumin capsules a few times a week with breakfast, or as directed by your health consultant.
* Curcumin and Turmeric supplement daily value not established

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Health benefit of curcumin supplement and turmeric supplement
Many human trials are needed before we can know with any certainty how we can best use curcumin in medicine. But one thing is certain: most doctors are not, at this time, aware of the potential benefits of curcumin and turmeric.

Curcumin supplement and Alzheimer's disease
In laboratory studies curcumin inhibits amyloid formation. Whether curcumin supplements help reduce the incidence of Alzheimer's disease or help improve this condition is not known at this time.
   Curcumin, one of the active chemicals in turmeric, the main spice found curry, may increase the clearance of amyloid plaques in the brain, the primary abnormality seen in patients with the disease. Dr. Milan Fiala, from the Greater Los Angeles Veteran's Affairs Medical Center, and colleagues found that immune cells called macrophages taken from patients with Alzheimer's disease cannot efficiently eliminate amyloid and that this may be related to the abnormal regulation of certain genes. Treating these cells with an active substance found in turmeric, called bisdemethoxycurcumin, increases the production of some of the genes and enhances macrophage function. Further studies are needed to determine if increasing blood levels of macrophages using an oral curcumin agent clear the amyloid plaques, and produce therapeutic effects, in patients with Alzheimer's disease, they add. Early Edition of the Proceedings of the National Academy of Sciences USA, July 16, 2007.

Curcumin anti-inflammatory benefit
The anti-inflammatory effect of curcumin extract involves many aspects of the immune system, including inhibition of the production of matrix metalloproteinases MMP-9 in peripheral blood mononuclear cells. Curcumin has an inhibitory effect on the production of inflammatory cytokines by human monocytes

Curcumin, turmeric and autoimmune disease benefit
Authoimmune diseases include multiple sclerosis, rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, thyroiditis, uveitis, systemic lupus erythromatosis, and myasthenia gravis. Curcumin extract may be of benefit in these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.

Curcumin supplement and ulcerative colitis benefit
Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial.
Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
Eighty-nine patients with quiescent ulcerative colitis were recruited for this randomized, double-blind, multicenter trial of curcumin supplement in the prevention of relapse. Forty-five patients received curcumin, 1g after breakfast and 1g after the evening meal, plus sulfasalazine or mesalamine, and 44 patients received placebo plus sulfasalazine or mesalamine for 6 months. Of 43 patients who received curcumin, 2 relapsed during 6 months of therapy (4%), whereas 8 of 39 patients (20%) in the placebo group relapsed. Recurrence rates evaluated on the basis of intention to treat showed significant difference between curcumin and placebo. Curcumin seems to be a promising and safe medication for maintaining remission in patients with quiescent ulcerative colitis.

Curcumin cancer benefit research
Curcumin supplement may help fight various forms of cancer. Studies evaluating the role of curcumin and cancer continue to advance at a fast rate.

Burkitt's lymphoma
In a test tube study, curcumin extract was found to have anticancer effects on human Burkitt's lymphoma.

Curcumin and breast cancer benefit
Curcumin exerts multiple different suppressive effects on human breast carcinoma cells in vitro. Curcumin extract also interferes with the spread of breast cancer tumor cells to lungs of mice. Curcumin suppresses proteins that tumor cells use to keep themselves immortal.

Q. I'm currently taking several grams per day of curcumin supplement to deal with breast cancer. Are you aware of anyone who has successfully treated their breast cancer with curcumin supplements.
   A. As of February 2008, we have not had feedback from anyone who has cured or treated breast cancer with curcumin supplements alone.

Curcumin and melanoma
In laboratory studies, curcumin interferes with the spread of melanoma cells. Tests in laboratory dishes show that curcumin made melanoma skin cancer cells more likely to self-destruct in a process known as apoptosis.

Benefit of curcumin for prostate cancer
Curcumin can enhance the cancer-fighting power of treatment with TRAIL, a naturally occurring molecule that helps kill cancer cells. TRAIL stands for tumor necrosis factor-related apoptosis-inducing ligand. In an experiment with human prostate cancer cells in a laboratory dish, the combination treatment killed off two to three times more cells than either treatment alone.

Curcumin and cholesterol
Curcumin supplements do not appear to play a significant role in blood lipid or cholesterol levels. However, as an antioxidant, it may protect oxidation of blood lipids.

Curcumin extract effects on blood lipid profile in a 6-month human study.
Pharmacol Res. 2007 Dec. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin extract on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects consumed 4 grams a day curcumin, 1g a day curcumin, or placebo in a 6-month, randomized, double-blind trial. The plasma curcumin concentration reached a mean of 490nmol/L. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. Curcumin extract consumption does not appear to have a significant effect on the serum lipid profile.

Curcumin, turmeric and liver health
Curcumin extract has anti-fibrotic properties and may play a role in the treatment of hepatic fibrosis.

Curcumin, turmeric and skin disorders
Curcumin may play a role in scleroderma, psoriasis and skin cancer. Curcumin protects skin by its antioxidant mechanisms. It also reduces skin inflammation through nuclear factor-KB inhibition. Curcumin treatment improves collagen deposition and increased fibroblast and vascular density in wounds thereby enhancing both normal and impaired wound-healing. Curcumin herbal extract may improve angiogenesis and accumulation of extracellular matrix.

Curcumin side effects
No apparent curcumin side effects have been reported in the medical literature thus far. Increased body temperature on high doses may be a possible curcumin side effect on high doses. A study performed at the University of Michigan showed no curcumin toxicity at doses up to 6 grams.
   Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006 Mar 17;6:10. Lao CD, Ruffin MT 4th, et al. University of Michigan, 2150 CCGC, Ann Arbor, MI.
   In phase I clinical studies, curcumin with doses up to 3600 to 8000 mg daily for 4 months did not result in noticeable side effects except mild nausea and diarrhea.

Compounds in the turmeric plant
Curcuma species contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is the most biologically active constituent of the spice turmeric and it comprises 2 to 8% of most turmeric preparations.

Curcumin turmeric mechanism of action
Curcumin extract possesses anti-inflammatory and anticancer properties. Many of these biological activities can be attributed to its potent antioxidant capacity, its inhibition of cell signaling pathways at multiple levels, its diverse effects on cellular enzymes, and its effects on cell adhesion and angiogenesis. Curcumin can alter gene transcription and induce cell death which makes it useful in the prevention of treatment of cancer.

Curcumin dosage
Q. What is the right dosage of curcumin for long term use?
   A. Each person may benefit from different amounts of curcumin supplements. It is reasonable and safe to consume one capsule of curcumin turmeric 500 mg a few days a week for long term health improvement. Higher amounts may be used for the treatment of a particular medical condition.

Curcumin turmeric emails and questions
Q. Is there curcumin turmeric research information on their effects on estrogen in women.
   A. We have not seen any research on the influence of curcumin and turmeric on estrogen levels.

Additional links of interest
Alpha lipoic acid supplement information
Coq10 coenzyme q10 supplement information
DHEA hormone information
Glucosamine arthritis information
Ray Sahelian, M.D. web site for more information on curcumin, turmeric supplements and natural health.
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Curcumin and turmeric questions
Q. Is curcumin herb useful of benefit for cancer treatment?
   A. Curcumin is an extract from the herb turmeric. Some early studies show curcumin to have potential in cancer prevention, and perhaps treatment, however extensive human studies are needed before any convincing statements can be made regarding the role of curcumin supplements in the treatment of cancer.

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Q. I have read that curcumin is not assimilated by the body without the addition of black pepper or piperine or Bioperine. Are pure curcumin supplements on the market of any use?
   A. Just about all the studies done with curcumin that have shown positive results have been done with pure curcumin without piperine, Bioperine or black pepper extracts.
 

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Dahlia pinnata have tuberous roots and showy colored flower heads.