Curcumin and Turmeric supplement 500 mg, 60 capsules
Joint Power Rx with turmeric, curcumin, boswellia, glucosamine and chondroitin
Developed by Ray Sahelian, M.D.

Curcumin
extract is one of the major antioxidant
extracts found in the spice
turmeric. The roots of the turmeric plant are used as an herb in Asian cooking such as curries. Curcumin
is a major component of turmeric herb (Curcuma longa) and extensive
scientific research on curcumin and turmeric has demonstrated their potent antioxidant
properties. Through their antioxidant mechanisms, curcumin and turmeric support
colon health, exert neuroprotective activity and help maintain a healthy
cardiovascular system.
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Supplement facts:
Curcumin extract and Turmeric herb 500 mg *
Usage: Take 1 or 2 curcumin capsules a few times a week with breakfast, or as directed by
your health consultant.
* Daily values not established
Health benefit of curcumin
supplement and turmeric supplement
Many human trials are needed before we can know
with any certainty how we can best use curcumin in medicine. But one thing
is certain: most doctors are not, at this time, aware of the potential
benefits of curcumin and turmeric.
Curcumin supplement and Alzheimer's disease
In laboratory studies curcumin inhibits amyloid formation.
Whether curcumin supplements help reduce the incidence of Alzheimer's disease or
help improve this condition is not known at this time.
Curcumin, one of the active chemicals in turmeric, the main spice
found curry, may increase the clearance of amyloid plaques in the brain,
the primary abnormality seen in patients with the disease. Dr. Milan Fiala, from the Greater Los Angeles Veteran's
Affairs Medical Center, and colleagues found that immune cells called
macrophages taken from patients with Alzheimer's disease cannot
efficiently eliminate amyloid and that this may be related to the abnormal
regulation of certain genes.
Treating these cells with an active substance found in turmeric, called
bisdemethoxycurcumin, increases the production of some of the genes and
enhances macrophage function.
Further studies are needed to determine if increasing blood levels of
macrophages using an oral curcumin agent clear the amyloid plaques, and
produce therapeutic effects, in patients with Alzheimer's disease, they
add. Early Edition of the Proceedings of the National Academy of
Sciences USA, July 16, 2007.
Dr. Tze-Pin Ng from National University of Singapore compared test results on mental health for three categories of regular curry consumption in elderly Asians who did not have dementia. People who consumed curry "occasionally" and "often or very often" had significantly better scores than did those who "never or rarely" consumed curry. These results, they say, provide "the first epidemiologic evidence supporting a link between curry consumption and cognitive performance that has been suggested by a large volume of earlier experimental evidence."
Curcumin anti-inflammatory
benefit
The anti-inflammatory effect of curcumin extract and
curcuminoids involves many aspects of the immune
system, including inhibition of the production of matrix metalloproteinases
MMP-9 in peripheral blood mononuclear cells. Curcumin has an inhibitory effect
on the production of inflammatory cytokines by human monocytes.
Curcumin, turmeric and
autoimmune disease benefit
Authoimmune diseases include multiple sclerosis, rheumatoid arthritis, type 1
diabetes, inflammatory bowel disease, thyroiditis, uveitis, systemic lupus
erythromatosis, and myasthenia gravis. Curcumin extract may be of benefit in these
autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6,
IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB
signaling pathways in immune cells.
Ulcerative colitis benefit
Curcumin maintenance therapy for
ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial.
Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
Eighty-nine patients with quiescent ulcerative colitis were recruited for
this randomized, double-blind, multicenter trial of curcumin supplement in the
prevention of relapse. Forty-five patients received curcumin, 1g after
breakfast and 1g after the evening meal, plus sulfasalazine or mesalamine, and 44 patients received placebo plus sulfasalazine or mesalamine for 6
months. Of 43 patients who received curcumin, 2 relapsed during 6 months
of therapy (4%), whereas 8 of 39 patients (20%) in the placebo group
relapsed. Recurrence rates evaluated on the basis of intention to treat
showed significant difference between curcumin and placebo. Curcumin seems to be a
promising and safe medication for maintaining remission in patients with
quiescent ulcerative colitis.
Curcumin and brain health
Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats.
Brain Res. 2008 September. Department of Pathophysiology, Chongqing Medical
University, Chongqing, 400016, PR China.
Recent studies have demonstrated that curcumin has protective effects against
cerebral ischemia /reperfusion injury. In the present study the brain
protective potential of curcumin was investigated in middle cerebral artery
occlusion (MCAO) induced focal cerebral IR injury. Administration of curcumin
100 and 300 mg/kg i.p. 60 min after MCAO significantly diminished infarct
volume, and improved neurological deficit in a dose-dependent manner. The
neuronal injury was significantly improved after being treated with curcumin.
Curcumin significantly decreased the expression of caspase-3 protein. Our
results suggest that the brain protective potentials of curcumin against focal
cerebral ischemic injury are, at least in part, ascribed to its anti-apoptotic
effects.
Cancer benefit research
Curcumin supplement may help fight various forms of cancer. Studies evaluating the
role of curcumin and cancer continue to advance at a fast rate. There are many
other herbs and extracts that have anti cancer benefits including
graviola and mangosteen.
Burkitt's lymphoma
In a test tube study, curcumin extract was found to
have anticancer effects on human Burkitt's lymphoma.
Breast cancer benefit
Curcumin exerts multiple different suppressive
effects on human breast carcinoma cells in vitro. Curcumin extract also interferes with the spread of
breast cancer tumor cells to lungs of mice. Curcumin suppresses
proteins that tumor cells use to keep themselves immortal.
Q. I'm currently taking several grams per day of curcumin
supplement to deal with
breast cancer. Are you aware of anyone who has successfully treated their breast
cancer with curcumin supplements.
A. As of February 2008, we have not had feedback from anyone who
has cured or treated breast
cancer with curcumin supplements alone.
Melanoma
In laboratory studies, curcumin
interferes with the spread of melanoma cells. Tests in laboratory dishes show that curcumin made melanoma skin cancer cells more likely to self-destruct in a
process known as apoptosis.
Prostate cancer
Curcumin can
enhance the cancer-fighting power of treatment with TRAIL, a naturally occurring molecule
that helps kill cancer cells. TRAIL stands for tumor necrosis factor-related
apoptosis-inducing ligand. In an experiment with human prostate cancer cells in a
laboratory dish, the combination treatment killed off two to three times more cells than
either treatment alone.
Cholesterol
Curcumin supplements do not appear to play a significant role in blood lipid or
cholesterol levels. However, as an antioxidant, it may protect oxidation of
blood lipids. Artichoke leaf
extract may be of benefit in managing cholesterol.
Curcumin extract effects on blood lipid profile in a 6-month human study.
Pharmacol Res. 2007 Dec. Department of Medicine and Therapeutics, The
Chinese University of Hong Kong, Shatin, Hong Kong.
Studies in animals and a short-term human study have suggested that curcumin, a
polyphenolic compound concentrated in the curry spice turmeric, decreases serum
cholesterol concentration. However, no controlled human trials have examined the
effect of curcumin extract on cholesterol. This study investigated the effects of
consuming curcumin on the serum lipid profile in men and women. Elderly subjects
consumed 4 grams a day curcumin, 1g a day curcumin, or placebo in a 6-month,
randomized, double-blind trial. The plasma curcumin concentration reached a mean
of 490nmol/L. Consumption of either dose of curcumin did not significantly
affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6
months. Curcumin extract consumption does not appear to have a significant effect on the
serum lipid profile.
Liver
health
Curcumin extract has anti-fibrotic properties and may play a role in the treatment of
hepatic fibrosis.
Parkinson's
disease
Curcumin treatment alleviates the effects of glutathione depletion in vitro and
in vivo: therapeutic implications for Parkinson's disease explained via in
silico studies.
Free Radic Biol Med. 2008 Mar 1. Jagatha B, Mythri RB, Vali S, Bharath
MM. Department of Neurochemistry, National Institute of Mental Health and
Neurosciences, 2900 Hosur Road, Bangalore, Karnataka, India.
An important biochemical feature of presymptomatic
Parkinson's disease
is a significant depletion of the thiol antioxidant glutathione in these
neurons resulting in oxidative stress, mitochondrial dysfunction, and ultimately
cell death. We have earlier demonstrated that curcumin, a natural polyphenol
obtained from turmeric, protects against peroxynitrite-mediated mitochondrial
dysfunction both in vitro and in vivo. Here we report that treatment of
dopaminergic neuronal cells and mice with curcumin restores depletion of
glutathione levels, protects against protein oxidation, and preserves
mitochondrial complex I activity which normally is impaired due to glutathione
loss. Using systems biology and dynamic modeling we have explained the mechanism
of curcumin action in a model of mitochondrial dysfunction linked to glutathione
metabolism that corroborates the major findings of our experimental work. These
data suggest that curcumin has potential therapeutic value for neurodegenerative
diseases involving glutathione depletion-mediated oxidative stress.
Pregnancy
and breastfeeding safety
Q. Is curcumin a safe supplement to take during pregnancy and/or
breastfeeding?
A. We have not seen safety studies in regards to curcumin or
turmeric use during breastfeeding or pregnancy, but we don't suspect small
amounts to cause any problems.
Rheumatoid arthritis
In experiments with rats, scientists at the University of Arizona in
Tucson found that turmeric extract was able to prevent rheumatoid arthritis-like
joint inflammation and destruction in the animals. The findings, published in
the journal Arthritis and Rheumatism, show that a turmeric extract like those
currently sold as dietary supplements has anti-arthritis powers. Rheumatoid
arthritis arises when the immune system mistakenly attacks tissue in the joints,
leading to inflammation, pain and progressive joint damage.
Skin
disorders
Curcumin may play a role in scleroderma, psoriasis and skin cancer.
Curcumin protects skin by its antioxidant mechanisms. It also reduces skin
inflammation through nuclear factor-KB inhibition. Curcumin treatment improves
collagen deposition and increased fibroblast and vascular density in wounds
thereby enhancing both normal and impaired wound-healing. Curcumin herbal
extract may improve
angiogenesis and accumulation of extracellular matrix.
Psoriasis
Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A
prospective clinical trial.
J Am Acad Dermatol. 2008 April. Kurd SK, Smith N, VanVoorhees A, Troxel
AB, Badmaev V, Seykora JT, Gelfand JM. Kurd SK, Smith N, VanVoorhees A, Troxel
AB, Badmaev V, Seykora JT, Gelfand JM. Department of Dermatology, University of
Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
We sought to determine the safety and efficacy of oral curcumin in
patients with psoriasis. We conducted a phase II, open-label, Simon's two-stage
trial of 4.5 grams per day of oral curcuminoid C3 complex in patients with
plaque psoriasis. The intention-to-treat analysis response rate was 16 and both
responders achieved a Psoriasis Area and Severity Index 75 score. Small sample
size and lack of placebo group were limitations. The response rate was low and
possibly caused by a placebo effect or the natural history of psoriasis. Large
placebo-controlled studies are necessary before recommending oral curcumin as a
psoriasis treatment.
Side effects
No apparent curcumin side effects have been reported in the medical literature
thus far. Increased body temperature on high doses may be a possible curcumin
side effect on high doses. A study performed at the University of Michigan
showed no curcumin toxicity at doses up to 6 grams.
Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006 Mar
17;6:10. Lao CD, Ruffin MT 4th, et al. University of Michigan, 2150 CCGC, Ann
Arbor, MI.
In phase I clinical studies, curcumin with doses up to 3600 to 8000
mg daily for 4 months did not result in noticeable side effects except mild
nausea and diarrhea.
Compounds in the turmeric plant
Curcuma species contain turmerin, essential oils, and curcuminoids, including
curcumin. Curcumin
[1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is the most
biologically active constituent of the spice turmeric and it comprises 2 to 8%
of most turmeric preparations.
Mechanism of
action
Curcumin extract possesses anti-inflammatory and anticancer properties. Many of these
biological activities can be attributed to its potent antioxidant capacity, its
inhibition of cell signaling pathways at multiple levels, its diverse effects on
cellular enzymes, and its effects on cell adhesion and angiogenesis. Curcumin
can alter gene transcription and induce cell death which makes it useful in the
prevention of treatment of cancer.
Curcumin dosage
Q. What is the right dosage of curcumin for long term use?
A. Each person may benefit from different amounts of curcumin
supplements. It is reasonable and safe to consume one capsule of curcumin
turmeric 500 mg a few days a week for long term health improvement. Higher
amounts may be used for the treatment of a particular medical condition.
Cur cumin and turmeric supplement questions
Q. Is there curcumin turmeric research information on their effects on
estrogen in women.
A. We have not seen any research on the influence of curcumin and
turmeric on
estrogen levels.
Q. Is curcumin herb useful of benefit for cancer treatment?
A. Curcumin is an extract from the herb turmeric. Some early
studies show curcumin to have potential in cancer prevention, and perhaps
treatment, however extensive human studies are needed before any convincing
statements can be made regarding the role of curcumin supplements in the
treatment of cancer.
Q. I have read that curcumin is not assimilated by the
body without the addition of black pepper or piperine or Bioperine. Are pure
curcumin supplements on the market of any use?
A. Just about all the studies done with curcumin that have shown
positive results have been done with pure curcumin without piperine, Bioperine
or black pepper extracts.
Q. I'm a naturopathic doctor who has beaten lung cancer entirely with natural methods. As part of my (and my clients') protocol, we take curcumin 500 mg and quercetin 500 mg mixed with 1 TBS olive oil -- mix well and take three times a day. Together they powerfully inhibit cancer cell growth and prevent many of the complications of chemotherapy.
I am a 63 year old female being treated with Avastin
injections to my left eye in connection with leaking vessels due to presumed
ocular histoplasmosis scars from childhood exposure to pigeons. Laser treatment
ten years ago in my left eye precludes further use of laser. I have lost the
central vision in the eye, but still have peripheral. My right eye has also been
lasered for abnormal vessels (in 2007), but I retain central vision in it and to
date have had no leaking vessels there. The only supplements I am currently
taking daily are Citrical with D and Genistein, and an 82 mg baby aspirin. Once
a week I take a Centrum Silver vitamin. We eat primarily vegetables and fruits,
and the only meat in our diet consists of boneless skinless chicken twice a week
and salmon once a week. I read recently on an American Foundation for the Blind
message board about a person who has been taking turmeric supplements for a
similar condition to mine and has not had any bleeding in the eye in nine years.
Would you please tell me which of your products containing turmeric might be the
best for me? Since reading the message board I've started adding turmeric to
soups and other vegetable preparations.
We only carry one type of curcumin turmeric product.
Clear Products
Clear Sinus and
Ear supplement
Clear
Products Clear Tinnitus supplement
Curculigo
orchioides Gaertn.is an important Ayurvedic as well as Unani herb.
Cydonia oblonga is
a shrub or small tree of the rose family known as quince fruit.
Cynara scolymus leaf
extract is widely used alone or in association with other herbs for embittering
alcoholic and soft drinks and to prepare herbal teas or herbal medicinal
products.
Dahlia pinnata
have tuberous roots and showy colored flower heads.
I have been very excited to read about the research on
tumeric, especially the research connected with inflammatory conditions namely
arthritis. I know that there has probably been no specific research
investigating the influence of tumeric cucumin on inflammatory myositis, but am
wondering if because of the way turmeric works for other inflammatoty conditions
whether it may help inflammatory myositis. I have had this autoimmune condition
for approximately 2 years although it was only diagnosed March 2009. I had a
muscle biopsy that showed accute inflammation of the muscles and fat of the
body. It has also affected tendons, and ligaments. The specialists are a bit
baffled by me as they profess not to have seen this type of inflammation before,
and are hazarding a guess that it is connected to another autoimmune disease I
have Crohns / ulcerative colits (at this point after having ulcerative colitis
for 20 years, they now say they are not sure whether it now may be crohns!) They
have me on immunosuppressants and steroids since March, but so far the
inflammation shows no sign of decreasing. Chemo is the next option so I am keen
to try anything else before resulting to this! I do hope you may be able to shed
some light on whether cucumin might be helpful for me.
It is not possible for us to predict any person's response to
natural supplements, but we wish you well.