Curculigo orchioides root

The rhizomes of Curculigo orchioides Gaertn. (Amaryllidacea) is an important Ayurvedic as well as Unani herb. It is present in several herbal formulations used in the treatment of menorrhagia and other gynecological problems.

Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides.
J Ethnopharmacol. 2007 November. Vijayanarayana K, Rodrigues RS, Chandrashekhar KS, Subrahmanyam EV. N.G.S.M Institution of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore 574160, Karnataka, India.
In this study, we conducted a comparative study of estrogenic activity of alcoholic extract of Curculigo orchioides with diethylstilbestrol in bilaterally ovariectomized young albino rats. Bilaterally ovariectomized albino rats were divided into five groups (n=9) receiving different treatments, consisting of vehicle (0.6% w/v sodium carboxy methyl cellulose), ethanolic extract of rhizomes of Curculigo orchioides at three different doses (viz., 300, 600, 1200 mg/kg body weight) and standard drug diethylstilbestrol (DES) at a dose of 2 mg/kg body weight. All these were administered orally daily for 7 days. Estrogenic activity was assessed by taking percentage vaginal cornification, uterine wet weight, uterine glycogen content and uterine histology as parameters of assessment. Alcoholic extract of Curculigo orchioides showed a significant increase in percentage vaginal cornification, uterine wet weight, uterine glycogen content and a proliferative changes in uterine endometrium compared to the control.

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