Curculigo orchioides root
The rhizomes of Curculigo orchioides Gaertn. (Amaryllidacea) is an important Ayurvedic as well as Unani herb. It is present in several herbal formulations used in the treatment of menorrhagia and other gynecological problems.
Evaluation of estrogenic activity of alcoholic extract of rhizomes of
Curculigo orchioides.
J Ethnopharmacol. 2007 November. Vijayanarayana K, Rodrigues RS, Chandrashekhar
KS, Subrahmanyam EV. N.G.S.M Institution of Pharmaceutical Sciences, Paneer,
Deralakatte, Mangalore 574160, Karnataka, India.
In this study, we conducted a comparative study of estrogenic activity of
alcoholic extract of Curculigo orchioides with diethylstilbestrol in bilaterally
ovariectomized young albino rats. Bilaterally ovariectomized albino rats were
divided into five groups (n=9) receiving different treatments, consisting of
vehicle (0.6% w/v sodium carboxy methyl cellulose), ethanolic extract of
rhizomes of Curculigo orchioides at three different doses (viz., 300, 600, 1200
mg/kg body weight) and standard drug diethylstilbestrol (DES) at a dose of 2
mg/kg body weight. All these were administered orally daily for 7 days.
Estrogenic activity was assessed by taking percentage vaginal cornification,
uterine wet weight, uterine glycogen content and uterine histology as parameters
of assessment. Alcoholic extract of Curculigo orchioides showed a significant
increase in percentage vaginal cornification, uterine wet weight, uterine
glycogen content and a proliferative changes in uterine endometrium compared to
the control.
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